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Dr Miller, expert in mental health, from BBC TV’s “The Secret Life of the Manic Depressive” Me with Lord Bragg, accepting my award. After graduating, I was recognised as being the ‘best young neurosurgeon in Britain’ Diet is the foundation for mental health. You actually need omega-3 for your brain cells so they function properly.

High dose fish oil response

Research was recently published in the June 2006 edition of The American Journal of Clinical Nutrition regarding fish oil. The principal researchers were MC Blonk, HJ Bilo, JJ Nauta, C Popp-Snijders, C Mulder and AJ Donker. The research was performed at The Department of Internal Medicine, Free University Hospital, Amsterdam, the Netherlands.

The study was entitled. Dose-response effects of fish-oil supplementation in healthy volunteers. The researchers performed a randomized, controlled study on the dose-response effects of daily supplementation of 1.5, 3, and 6 grams of the marine fatty acids eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) as their ethyl esters for 12 week in 45 healthy normotriglyceridemic male volunteers.

Significant dose-related increases of the n-3 fatty acids 20:5, 22:5, and 22:6 in plasma phospholipids (p less than 0.0001) were found, corresponding roughly to decreases of the n-6 fatty acids 18:2 and 20:4 (p less than 0.001). Serum triglycerides and HDL3-cholesterol concentrations showed a dose- dependent reduction (p less than 0.05) and HDL2 cholesterol increased (p less than 0.05). Results for 3 and 6 g n-3 fatty acids were similar. No dose-dependent effects were observed in the VLDL-, LDL-, and total HDL-cholesterol sub fractions; blood pressure; bleeding time; erythrocyte deformability; or capacity of polymorphonuclear leukocytes to kill Staphylococcus aureus.

This study indicates that 3 g n-3 ethyl ester fatty acids appears to be the appropriate supplementation dose in humans, at least regarding lipid-profile changes and the ability to incorporate such fatty acids in the plasma phospholipids.

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