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Fish-oil Supplementation: Impact on Lipid Profile of Healthy Men
The European Journal of Heart Supplements published an article on June 1, 2001. This article summarized research about the topic of fish oils and fish diets. The title was; A mixed Australian fish diet and fish-oil supplementation: impact on the plasma lipid profile of healthy men. The head researchers on this study were AJ Brown, DC Roberts, JE Pritchard and AS Truswell. They performed their research and study at the Department of Biochemistry, University of Sydney, NSW, Australia.
In this study twelve healthy men, all randomly selected, were fed in turn three diets. The study lasted for 6 weeks each in a 3 x 3 randomized block design. The control diet, which was essentially fish free, a fish diet (200 g lean Australian fish flesh per day), and the same fish-based meal but supplemented with 5 g of fish oil per day. Dietary eicosapentaenoic acid [EPA, 20: 5n-3 (omega-3)] was strongly associated with erythrocyte membrane EPA (r = 0.908 at 6 wk), strengthening its value as a measure of compliance in fish and fish-oil feeding trials.
On the fish diet, subjects had increased incorporation of n-3 polyunsaturated fatty acids (PUFAs) at the expense of n-6 PUFAs in their erythrocyte membranes. When the fish-based diet was supplemented with fish oil (5 g/d), there was a significant lowering of plasma triacylglycerol (-0.16 +/- 0.24 mmol/L; mean +/- SD).
Conclusion, no change in the plasma total cholesterol was detected although the fish and oil diet produced a reduction in very-low- density-lipoprotein cholesterol (-0.24 +/- 0.26 mmol/L). | | |
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