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Fish Oil on Lymphocyte Proliferation
This studies background is that Prostaglandin E2 inhibits lymphocyte proliferation and the production of interferon- by peripheral blood mononuclear cells, but the effect of PGE2 on interleukin 4 production is unclear.
Fish oil, which contains eicosapentaenoic and docosahexaenoic acids, inhibits production of PGE2. The effects of fish oil on lymphocyte proliferation and production of IFN- and IL-4 are unclear and may be influenced by the availability of antioxidants. The researchers objective: investigate the effect of dietary fish oil with and without antioxidant co-supplementation on lymphocyte proliferation and the production of PGE2, IFN-, and IL-4 by peripheral blood mononuclear cells.
In the study design, sixteen healthy men received dietary fish oil supplements providing 0.3, 1, and 2 g eicosapentaenoic acid plus docosahexaenoic acid/d for 4 consecutive weeks each (total of 12 wk). All subjects were randomly assigned to daily co supplementation with either antioxidants (200 µg Se, 3 mg Mn, 30 mg RRR--tocopheryl succinate, 90 mg ascorbic acid, 450 µg vitamin A) or placebo.
The researchers results were that fish oil supplementation decreased PGE2 production and increased IFN- production and lymphocyte proliferation from baseline values. Co supplementation with antioxidants did not affect cytokine production or lymphocyte proliferation. Dietary fish oil modulates production of IFN- and lymphocyte proliferation in a manner consistent with decreased production of PGE2, but this effect is not modified by antioxidant co supplementation.
The principal researchers were Timothy M Trebble, Stephen A Wootton, Elizabeth A Miles, Mark Mullee, Nigel K Arden, Anne B Ballinger, Mike A Stroud, Graham C Burdge and Philip C Calder. They named the study prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant co-supplementation. The research was published The American Journal for Clinical Nutrition, in June of 2006.
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