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Fish Oil and Triacylglycerol Structure

In the Journal of Lipid Research in November 1, 2003 researchers published their work on Differential incorporation of fish oil eicosapentaenoate and docosahexaenoate into lipids of lipoprotein fractions as related to their glyceryl esterification: a short-term (postprandial) and long- term study in healthy humans. H Sadou, CL Leger, B Descomps, JN Barjon, L Monnier and A Crastes de Pauletwere the researchers at Laboratoire de Biologie et Biochimie des Lipides, Inserm et Service des Maladies, Metaboliques, Centre Hospitalier Universitaire de Montpellier, France.

The researchers investigated how the distribution of eicosapentaenoate and docosahexaenoate in the sn-2 and sn-1(3) positions of fish oil triacylglycerols influenced their respective incorporation into triacylglycerol, cholesterol esters, and phospholipids of two lipoprotein fractions: low- and very-low-density lipoprotein (VL/LDL) and high-density lipoprotein (HDL). Nine healthy volunteers were studied over both a short-term (0-8 hours) and a long-term (30 days) postprandial period of daily supplementation with 2 g EPA and 1.3 g DHA given as 11 g fish oil triacylglycerol in which DHA was predominantly situated in the sn-2 position.

The researchers results strongly suggest that the higher triacylglycerol incorporation of DHA and the higher metabolic availability of EPA compared with DHA for phospholipid accumulation (particularly in the short-term study) depend on their respective preferential sn-2/sn-1(3) positions in fish oil triacylglycerol, emphasizing the important role of the triacylglycerol structure and its potential manipulation for modulating availability of either or both fatty acids.

Omega 3 fish oils Pure EPA is available exclusively from mind 1st.

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